Activity (necroinflammation) and fibrosis are two major histologic features of chronic hepatitis C included in different proposed classifications. One of the few validated scoring systems is ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

The new study in The American Journal of Pathology, published by Elsevier ... Idiopathic pulmonary fibrosis (IPF) is a devastating progressive fibrotic lung disease with a median survival of ...

More information: Margaret A.T. Freeberg et al, Piezo2 Is a Key Mechanoreceptor in Lung Fibrosis that Drives Myofibroblast Differentiation, The American Journal of Pathology (2025). DOI ...

Piezo2 is increased in idiopathic pulmonary fibrosis (IPF). Immunohistochemistry of nonfibrotic (left) and IPF (right) lung tissue demonstrating that Piezo2 (brown staining) is strongly present in ...

In late-stage DAD, the researchers saw an increase of markers associated with lung fibrosis—a lung pathology that causes ...

The findings emphasize the importance of exosomal lncRNAs, which function as molecular regulators in kidney pathology and hold ... ultimately resulting in renal fibrosis and organ failure.