生物通25 天
细胞间 “脂质信使” 揭秘慢阻肺发病新机制：肺巨噬细胞外泌神经 ...
为探究神经酰胺在慢阻肺（COPD）发病中的细胞间作用，研究发现其经细胞外囊泡（EVs）传递损害内皮功能，为治疗提供新靶点。 慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease，COPD）是一种常见的肺部疾病，主要由吸烟等因素引发，严重影响患者的呼吸功能 ...
Frontiers1 年
ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics
The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter of debate. In this work, we report our real-life experience with EGPA patients, treated ...
Nature1 年
RNA granules: post-transcriptional and epigenetic modulators of gene expression
“...RNA granule-mediated post-transcriptional and epigenetic alterations in protein expression are remnants of an ancient RNA world...” An important consequence ...
eLife2 年
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit. A recent study showed ...
eLife7 年
Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent ...
Newly synthesized membrane proteins are targeted to the inner nuclear membrane (INM) by diffusion within the membrane system of the endoplasmic reticulum (ER), translocation through nuclear pore ...