This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

为探究心肌细胞增殖调控机制及治疗心肌梗死，研究发现 circALPK2/miR-9/GSK3B 轴可促进心肌再生 ... circALPK2 作为一种负调控因子，通过海绵机制抑制 miR-9，进而上调 GSK3β 的表达，抑制 WNT 信号通路，最终抑制心肌细胞增殖和心脏修复。敲低 circALPK2 则可打破这种 ...

Forbes contributors publish independent expert analyses and insights. Asif Burhan is a freelance journalist who covers women's soccer.

肝细胞癌（HCC）是世界上最致命的恶性肿瘤之一，其发病率和死亡率逐年上升。HCC的研究越来越集中于了解其发病机制和开发治疗方法。Wnt信号通路是一个复杂且进化保守的信号转导系统，在多种恶性肿瘤的发生和治疗中得到了广泛的研究。最近的研究表明，HCC ...

There are currently 35 places between Ireland (25) and Türkiye (60) in the FIFA Women’s World Rankings. - Türkiye will become the 55th different team that Ireland will have faced for the first time at ...

The major signaling pathways involved in the developmental process, such as Notch, Hedgehog, and Wnt, play a vital role in development, tumorigenesis, and also in the resistance to the various ...

The factors in the TME and signaling networks that program DCs to a regulatory state are not fully understood. Recent advances point to novel mechanisms by which the canonical Wnt signaling cascade in ...

2019). In the present study, we describe a gradient-independent Wnt signaling in instructing stereotyped developmental neurite pruning of the PDB cholinergic motor neuron in C. elegans. From genetic ...

The cells in our body communicate with each other to coordinate many essential processes, including cell division and the formation of tissues and organs. The Wnt signaling pathway is crucial for cell ...