In 2000, Zhang & Clarke used a strategy with artificial beads to prove the direct function of Ran GTPase in NE assembly. The artificial beads are made of solid sepharose, and thus have the ...

One of the most powerful ways of studying the function of a protein is to specifically ... as mutant Ras proteins that lack GTPase activity, which normally turns Ras off, were found in many ...

Loss-of-function variants in ITSN1 confer high risk ... The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons ...