该研究首次阐明Miro1 N端GTPase结构域在神经分化中的核心调控作用，为预防产前应激导致的神经精神疾病提供新靶点。 在生命早期，母体经历的应激事件可能通过胎盘屏障影响胎儿神经发育，这种"编程效应"往往导致子代成年后出现认知障碍和情绪异常。尽管已知 ...

One of the most powerful ways of studying the function of a protein is to specifically ... as mutant Ras proteins that lack GTPase activity, which normally turns Ras off, were found in many ...

Loss-of-function variants in ITSN1 confer high risk ... The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons ...