This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of ...

Importantly, both IL-1B and GADD45B levels were significantly increased in the exosomes and UV-challenged ... For apoptosis, we examined the key markers Bcl-2, Caspase 3, and p53, while for ...

为阐明分子机制，研究整合RNA-seq和iRIP-seq两大关键技术：前者揭示RBM24调控301个差异表达基因(DEGs)，其中促凋亡基因GADD45B等上调，炎症相关基因S100A9等下调；后者首次绘制了RBM24在OSCC中的RNA结合图谱，发现其优先结合AU富集区并靶向NEAT1等lncRNA。 研究结果部分 ...

转录组学和蛋白质组学测序结果揭示，FTD/TPI 处理后 RKO 细胞的相关基因和蛋白质发生了显著变化，涉及多个细胞死亡途径，尤其影响了铁死亡调节途径，其中转录因子 p53 上调，SLC7A11 基因下调。 FTD/TPI 诱导 CRC 细胞死亡 研究人员用铁死亡抑制剂（ferrostatin - 1 ...

Senolytic drugs work in senescent cells by selectively inducing apoptosis. These drugs target specific pathways like the BCL-2 family, p53, and the PI3K/AKT pathway, crucial for the survival of ...