Gaba is the wellness world’s latest buzzword. It’s made by our bodies and acts like serotonin or dopamine. Here’s what you ...

The activation of AMPARs by glutamate is an extremely rapid process, so previous studies have used drugs to slow it down. These are typically positive allosteric modulators (PAMs), which block a ...

Headquartered in Bresso, near Milan, Italy, Newron is advancing its lead compound, evenamide, a first-in-class glutamate modulator, which has the potential to be the first add-on therapy for ...

Aditum funded Tempero, while Soshei licensed a suite of metabotropic glutamate receptor 5 (mGlu5) NAM modulator molecules, including TMP-301. These molecules modulate glutamate signaling in the brain, ...

TMP-301 is a metabotropic glutamate receptor 5 (mGluR5)-negative allosteric modulator (NAM), which plays a role in central nervous system function. Tempero said that the candidate can prevent relapse ...

This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR 2). The chemical synthesis, ...

This is evident in median raphe neurons, which co-express serotonin and glutamate and segregate these neurotransmitters into distinct axonal branches that innervate different brain regions. For ...

GABA, an inhibitory neurotransmitter, and related nutritional therapies are promising in restoring these imbalances. GABAergic deficits and glutamate excitotoxicity are two essential signaling ...

Headquartered in Bresso, near Milan, Italy, Newron is advancing its lead compound, evenamide, a first-in-class glutamate modulator, which has the potential to be the first add-on therapy for treatment ...