2021). 3.2 Dual/tri-targeting strategies of CAR-T cell therapy in GBM treatment Macrophages can be engineered to produce BiTEs, which are fusion proteins that link T cells to tumor cells, facilitating ...

Researchers discovered that EBV infection triggers macrophage pyroptosis—a form of inflammatory cell death—by accelerating glycolysis, a key metabolic pathway. This cascade of events worsens colonic ...

Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory.

As for macrophages, SIRT3/4/5 affect macrophage metabolism in OXPHOS, glycolysis and FAO, illustrating that mtSIRT reconciles the metabolic state of macrophages to meet their demands. Unfortunately, ...

Researchers discovered that EBV infection triggers macrophage pyroptosis—a form of inflammatory cell death—by accelerating glycolysis, a key metabolic pathway. This cascade of events worsens ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages ...

Macrophages, part of the innate immune system, can exhibit a form of immune memory by adjusting their molecular signaling after an infection. This adaptation can either enhance or reduce their ...

Now, researchers at the University of Chicago Pritzker School of Molecular Engineering have discovered a new form of immune memory. Macrophages, a type of white blood cell, adjust their molecular ...

The rapid spread of the highly infectious avian flu virus H5N1 has reached an “unprecedented” scale, wiping out hundreds of millions of birds worldwide and increasingly spilling over into mammals, the ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages ...