PPA2 expression levels are reduced in CRC specimen and correlate with enhanced response to hypoxia by promoting hypoxia-inducible factor-1 (HIF-1) signaling to promote CRC cell glycolysis and ...

Aerobic glycolysis is upregulated through the inhibition of PDH by PDK, thereby blocking Acetyl Co-A synthesis, and through the upregulation of LDHA, which produces lactate. PFK-2 and PK-M2 are ...

Lactate affects glucose metabolism by inhibiting cellular glycolysis and maintaining mitochondrial homeostasis through the inhibition of glycolytic enzymes (HK-1, PKM) and the promotion of TCA cycle ...

As Jiri Kulich lay on the ice in distress Saturday afternoon, Peyton Krebs darted toward Brett Howden and challenged the Vegas Golden Knights’ winger to a fight. Krebs dropped his gloves ...

Authorities in India today arrested the alleged co-founder of Garantex, a cryptocurrency exchange sanctioned by the U.S. government in 2022 for facilitating tens of billions of dollars in money ...

This cycle is vital to all of Earth’s life forms- both directly and indirectly. Without it, life as we know it will cease to exist. Water is one of the primary natural elements, covering about ...

In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and ...

Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine ...