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生物通
1 个月
揭秘 ABC 转运蛋白 Tba 的底物特异性及其在糖肽生物合成中的关键作用
在微生物的奇妙世界里,抗生素的合成与运输一直是科学家们热衷探索的领域。糖肽抗生素(Glycopeptide antibiotics,GPAs)作为一类重要的抗生素,由放线菌合成,像万古霉素、替考拉宁等,它们是治疗耐药革兰氏阳性菌感染的 “最后防线” 。基于独特的肽骨干 ...
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