A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in ...

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

This study achieved CRISPR/Cas9-mediated genome editing in grass carp (Ctenopharyngodon idella), China's most economically vital freshwater fish. Targeting the tyrb gene critical for pigmentation were ...

A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

It can deliver its payloads, including genome editing compounds such as CRISPR-Cas9, gRNA and DNA, directly to the targeted nucleus without harming the cell. It can be programmed to recognize cell ...

However, both the Cas9 and Cas12 nucleases show some tolerance for guide RNA (gRNA) and target site mismatches, which may ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Genome editing by CRISPR/Cas9 system is a popular laboratory technique used in ... of the constructs with fluorescence microscopy and assess the functionality of the gRNA with a T7 nuclease mutation ...