We found that the three DNA-damaging drugs, namely Nutlin, Doxorubicin, and 5-Fluorouracil (5-FU), stabilized p53 and concurrently repressed BLM and RAD51 in both HCT116 WT and HCT116 p21−/− cells but ...

1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. 2Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, China. 7Suzhou Biomedical ...

Methods: In this study, we employed in situ ChIA-PET to investigate the colorectal cancer cell line HCT116 with p53 knockout, comparing them to cells infected with the adenovirus-vector expressing p53 ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

为探究 TRIM26 与 p53 在结直肠癌（CRC）中的关系，[第一作者单位名称] 研究人员开展相关研究。结果发现 TRIM26 可促进 CRC 细胞增殖和肿瘤生长，或可作潜在治疗靶点。推荐一读，助您了解癌症研究新进展。 在癌症研究的神秘领域中，有一个 “神秘嘉宾 ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

Inhibition of activity was reported as a percentage of the activity of vehicle-treated cells, and the IC 50 value was calculated using the Excel XLfit add-in. HCT116 or LS411N MSI-H/dMMR and NCI-H747 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Colorectal cancer (CRC) is a major health ...