Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship Bispecific antibodies (bsAbs) have emerged as a novel class of therapeutics, ...

*-Split conference with 2A schools — 1-seeds must have an overall win percentage of .500 or better OR finish in the top three in the conference standings to be seeded with the 1-seeds, or else be ...

这篇综述聚焦慢性脑灌注不足（CCH）引发的血管性痴呆（VaD），探讨缺氧诱导因子 1α（HIF-1α）的双重作用。HIF-1α 早期可通过 VEGF 信号促血管生成发挥神经保护作用，但长期激活会引发氧化应激等不良影响。深入研究其机制对治疗 VaD 意义重大。 慢性脑灌注不足 ...

Fang et al. find that in cell line models of TNBC, STAMBPL1 promotes expression of the transcription factor HIF-1a and its downstream target VEGF, with the consequence of stimulating neo-angiogenesis ...

Hepatocyte death (apoptosis, pyroptosis ... Bcl-2: B-cell lymphoma-2; Bcl-XL: B-cell lymphoma-extra large; CDKN: cyclin-dependent kinase inhibitor; ER: endoplasmic reticulum; HIF-1a: hypoxia-inducible ...

Background Injured or reactive biliary epithelial cells participate in most chronic liver injuries in a process referred to as ductular reaction, which involves multicellular interactions with marked ...

INVESTIGATORS AND CLINICIANS anticipate that the next wave of therapeutic approaches in renal cell carcinoma (RCC) will target hypoxia-inducible factor-2 (HIF-2), a transcription factor that is ...

Stage 1a vs. Stage 1b Staging is a refinement of a general diagnosis that describes how advanced a cancer is. Lung cancer is staged based on the TNM system, in which T stands for tumor size, N stands ...

Liver regeneration was known to occur through the proliferation of liver cells, known as hepatocytes. However, the molecular mechanisms involved were not fully understood. This current discovery ...

District 6 dynamo Bishop Guilfoyle is back in Hershey trying to win its second straight PIAA 1A girls basketball title. In the way is two-time District 3 champ Linville Hill Christian. The two ...

S.W. Chung and J.S. Kim equally contributed to this article as co-first authors. W.-M. Choi and K.M. Kim equally contributed to this article as co-corresponding authors.