Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States Alnylam ...

IFN-γ release assays do not differentiate between ... Development of promising host markers into rapid, dipstick-like tests will enhance the diagnosis of TB disease at point-of-care settings.

Adipocyte-derived ADPN promoted M2 polarization and sustained mitochondrial quality via the ADPN/AdipoR2/HMGB1 axis. Mechanistically ... The following cytokines were measured: GM-CSF, IFN-γ, IL-1β, IL ...

However, tumor marker tests aren’t the only tools they’ll use in cancer care. Other testing techniques will help provide a more comprehensive look at your type of cancer. Regular cells may ...

In the present review, we focus on the impact of type I IFNs on anti-tumor responses, driven by monocytes and macrophages. Specifically, we will provide an overview of tumor-intrinsic factors, which ...

为探究 HMGB1 在食管鳞状细胞癌（ESCC）中的作用机制，研究人员开展相关研究，发现其与 ESCC 细胞增殖、巨噬细胞极化有关，为 ESCC 治疗提供新依据。 在人体的微观世界里，癌症就像一群肆意捣乱的 “小怪兽”，严重威胁着人类的健康。其中，食管癌（EC ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common and severe cerebrovascular disease ...

Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People’s Republic of China Department of Chemistry, National University of ...

Each IFN has a unique metabolic signature, with IFNG being the most associated with activation of the kynurenine pathway. IFNs also show differential relationships with clinical markers of poor ...

High-mobility group protein 1 (HMG1, encoded by HMGB1) is a nonhistone nuclear ... particular cytokines are elevated (e.g. increased interferon expression in patients with systemic lupus ...

We found that TBI leads to an upregulation of type I interferon (IFN) signature genes in macrophages and a controlled upregulation of inflammatory-related genes in the fibroblast and adaptive immune ...