这篇研究聚焦人乳头瘤病毒（HPV）相关宫颈癌。发现视网膜母细胞瘤蛋白（pRB）不仅是 HPV E7 的降解靶点，还对 E7 蛋白稳定至关重要。pRB 缺失会降低 E7 水平，抑制癌细胞增殖，为 HPV 相关癌症研究提供新思路。

In this article we give an overview of RNA-based HPV diagnostics and the role of E6/E7 mRNA detection as a predictive marker for the development of cervical carcinoma. HPV E6/E7 mRNA testing for ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

The E6 and E7 proteins are key oncogenes in the development of HPV-associated tumors, and therapeutic vaccines targeting HPV16 E6 and E7 tumor-specific antigens -- such as Vvax001 -- "represent an ...

The researchers can model this either by editing the genes themselves or inhibiting their expression with HPV E6 and E7 oncoproteins. These two oncoproteins help drive HPV-associated cancers by ...

Enzo’s innovations are changing the story of HPV. The FLOWSCRIPT® Assay employs a novel, flow cytometry-based, in situ hybridization technique, utilizing a cocktail of probes specific to multiple ...