Targets for degradation are redirected to the proteasome through interaction with co-chaperones, including the C-terminus of HSC70-interacting protein (CHIP) and Bcl2-associated athanogene 1 (BAG1), ...

Among them, heat-shock protein 90 (Hsp90) stands out as an essential proteostasis hub in eukaryotes, chaperoning hundreds of ‘clients’ (substrates). After decades of research, several ‘known unknowns’ ...

Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...