Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

The initial proof of concept studies in human heart cells and engineered heart tissue showed that the gene-vector-promoter construct corrects MyBP-C protein levels/expression in the sarcomere and ...

(A) The basic organization of a sarcomere subregion, showing the centralized location of myosin (A band). Actin and the z discs are shown in red. (B) A conceptual diagram representing the ...

It is caused by mutations in sarcomere protein genes ... and conducted at the TUM University Hospital German Heart Center by leading HCM expert Prof. Dr. Cordula Wolf. Poxel and the TUM University ...