Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

Meaghan started at UMass Lowell in the fall of 2019 where she joined Professor Jeffrey Moore's lab. Her research is focused on the mechanism of sarcomere proteins in heart muscle contraction. She aims ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

The initial proof of concept studies in human heart cells and engineered heart tissue showed that the gene-vector-promoter construct corrects MyBP-C protein levels/expression in the sarcomere and ...