These compounds induce a variety of hepatotoxic responses including peroxisomal proliferation, hepatic necrosis and apoptosis, cholestasis, DNA damage, protein synthesis inhibition, oxidative ...

An estimated 15.6 million adults in the U.S. reported use of at least one potentially hepatotoxic botanical supplement within ...

MANY of the natural pyrrolizidine alkaloids isolated from various plants are not only acutely hepatotoxic, but are also able to produce subacute and chronic liver lesions in rats when given in an ...