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29 天
《Nature》哺乳动物整合应激反应的可塑性:从机制到疾病洞察
发现 eIF4E - DDX3X 轴在 s-ISR 中对 uORF1 介导的 ATF4 诱导起特定作用,而在 c-ISR 中似乎未显著参与。此外,适度低血糖可通过 GSK3 触发 s-ISR,在 Herceptin 耐药的乳腺癌细胞模型中,ER 应激后 s-ISR 在耐药细胞中被诱导,而在亲本敏感细胞中未被诱导,这为理解 s-ISR 的 ...
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