PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, ...

Blood was collected 4 h post TNF-α challenge and serum was isolated for further examination. Methods for Determination of CYP/hERG Inhibition and Pharmacokinetic Parameters Cytochrome P450 (CYP) ...

A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...

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Because of these effects, understanding the out-of-pocket costs for SGLT-2 inhibitors is essential. However, estimates for out-of-pocket costs are limited with no nationally representative or ...

Cancer cells sometimes use these checkpoints to avoid being attacked by the immune system. Drugs that target these checkpoints (called checkpoint inhibitors) can be used to treat some people with ...

Given these similarities in channel topology and components, how is it that KCNQ1, hERG, and SCN5A perform such distinct functions, and produce phenotypically distinct forms of LQTS? To explore this ...