Persistent Link: https://ieeexplore.ieee.org/servlet/opac?punumber=6287639 ...

However, NMDAR dysregulation is implicated in many nervous system disorders. Diseases that involve pathological hyperactivity of NMDARs can be treated clinically through inhibition by channel blocking ...

A novel topical formulation of a BRAF inhibitor significantly reduced acneiform rash associated with anti–epidermal growth factor receptor (EGFR) therapies in patients with colorectal cancer ...

Companies like Eli Lilly, Regeneron Pharmaceuticals, and Scholar Rock are attempting to prevent this muscle loss through the therapeutic inhibition of myostatin using antibodies and other methods.

In a recently published phase 2b extension study, adding narrow-band ultraviolet B (nbUVB) phototherapy to ritlecitinib, an oral Janus kinase (JAK) 3/tyrosine-protein kinase inhibitor, resulted in ...

These agents should effectively block signaling through both the IRAK- and FLT3-mediated pathways, and should thus offer improved efficacy relative to the FLT3 inhibitors that have advanced previously ...

Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China Introduction: Prior cohort studies reported paradoxical results between proton pump inhibitor (PPI) ...

1Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts. 2Harvard Medical School, Boston, Massachusetts. 3Broad Institute of MIT and ...

1Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois. *Corresponding Author: Hilary A. Kenny, Department of Obstetrics and Gynecology, ...

"The initiation of this clinical trial marks an important milestone in advancing our novel WRN inhibitor program," said Anita Scheuber, M.D., Ph.D., Senior Vice President, Therapeutic Head, Oncology ...

Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their ...