The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study from the USC Stem ...

A USC research team discovered that a single genetic signal may be preventing both hearing and vision cells from repairing ...

在研究结论和讨论部分，该研究首次全面鉴定了与 AMI 中 Hippo 信号通路相关的生物标志物，包括 NAMPT、CXCL1、GIMAP6 和 GIMAP7，为开发针对 AMI 的靶向治疗提供了理论基础。尽管研究存在一定局限性，如使用的数据集在以往研究中被广泛应用、样本量相对较小等，但研究结果仍具有重要意义。这些生物标志物不仅具有临床诊断潜力，还为深入理解 AMI ...

Among these signals, the TGF-β and HIPPO pathways are critical, functioning as tumor suppressors and regulating liver development and regeneration. The review focuses on these pathways' interplay ...

Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...

The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...

Latigo Biotherapeutics, Vivace Therapeutics, and Vori Health each announced the recent successful closing of their respective ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit flies and another important for the growth of embryos -- interact in embryonic mouse hearts to restrict cell ...

SAN MATEO, Calif., March 12, 2025 /PRNewswire/ -- Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class cancer therapies targeting the Hippo pathway, ...

VT3989 is a transcriptional enhanced associate domain (TEAD) autopalmitoylation inhibitor that blocks the palmitoylation of TEAD protein family members to target the Hippo pathway. RA Capital ...