The basic building blocks of chromatin are nucleosomes, each of which is composed of 146 bp of DNA wrapped around a histone octamer ... of the chromatin state, which governs gene transcription ...

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

Our hypothesis rests on the central concept that mammalian histone H3 variants (H3.1, H3.2, and H3.3), although remarkably similar in amino acid sequence, exhibit distinct posttranslational ...

H3K79 methylation is a histone modification driven by the disruptor of telomeric silencing 1 (DOT1L) methyltransferase (Martin and Zhang, 2005). Unlike the previous residues, H3K79 is part of the ...

Immunoprecipitation of histone deacetylase activity from cell extracts. We carried out immunoprecipitations as described above with Hela nuclear extracts (50μl; Computer Cell Culture Centre ...

New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in ...

New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

Suzanne is a content marketer, writer, and fact-checker. She holds a Bachelor of Science in Finance degree from Bridgewater State University and helps develop content strategies. izusek / Getty ...

Angiogenesis is the physiological process of new blood vessel formation by endothelial cells. Many different growth factors, including vascular endothelial growth factor (VEGF), basic fibroblast ...

New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 ...