A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...

Interferon gamma (IFN-γ) is a cytokine that induces a series of immune responses against viruses and tumors. The pro-apoptotic, anti-tumor and anti-proliferative actions of the cells are ...

The STAT family has six members (STAT1–6), each of which transduces the signal of particular cytokines. For instance, signaling from the interferon (IFN) receptors, interleukin-4 (IL-4 ...

IFN-α2 (in most centers today pegylated IFN-α2 [Peg-IFN-α2]) induces major or complete molecular remissions in a subset of JAK2V617-positive patients with essential thrombocythemia (ET) and ...

removal of this inhibitory signal leads to reactivation of T cells. In vitro functional assays have shown that IFN-γ secretion increased in the presence of ABL403T and ABL403 (indicating T cell ...

The investigators showed that RAR-induced cell death is potentiated by addition of recombinant IFN-b. Based on the current study and previously published work, the investigators propose a model ...