研究者们通过对GEO数据库中的多个数据集分析发现，在IPF患者和BLM诱导的小鼠肺纤维化模型中，STX11的表达显著降低。进一步实验表明，过表达STX11能够抑制TGF-β1诱导的成纤维细胞活化，并通过促进自噬过程减弱纤维化进展。更有趣的是，STX11与SNAP25相互作用形成复合物，该复合物可阻断PI3K/AKT/mTOR信号通路，从而影响成纤维细胞的增殖、分化等关键生物学行为。

Cumberland Pharmaceuticals Inc. (Nasdaq: CPIX), a specialty pharmaceutical company with development efforts focused on new products for rare diseases, today announced a partnership with Qureight, a ...

Tvardi Therapeutics, Inc. ("Tvardi") , a clinical-stage biopharmaceutical company focused on the development of novel, oral, small molecule therapies targeting STAT3 to treat fibrosis-driven diseases, ...

A drug that is currently used for cancer could be the key in treating a disease that has no cure, and a life expectancy of ...

A cancer drug could help a condition which is incurable and fatal with many of those who have the condition dying within 3 ...

A little-known drug may offer hope for a currently incurable and deadly condition, with many patients dying within three ...

According to DevelInsight analysis, the estimated total diagnosed prevalent cases of Idiopathic Pulmonary Fibrosis in the 7MM were approximately 193,000 in 2023; this number is expected to increase in ...

PF encompasses over 200 ILDs, with idiopathic pulmonary fibrosis (IPF) being the most common and severe form. Histopathologically, PF features chronic inflammation, fibroblast proliferation ...

Environmental and Occupational Exposure: Chronic inhalation of inorganic and organic particulates, such as silica, asbestos, ...

“In healthy lungs, specialized cells known as fibroblasts assist in repairing lung tissue; however, in individuals with IPF, certain fibroblasts and adjacent epithelial cells become dysfunctional,” ...