Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...

Studies suggest that by acting as a decoy receptor for myostatin—a protein believed to inhibit muscular tissue ...

Finally, the IFNAR system perfectly illustrates the paradigm of the crosstalk between membrane trafficking and intracellular signaling. Investigating the complexity of IFN receptor intracellular ...

Specifically, the authors demonstrate that distinct GsPCRs differentially regulate cardiomyocyte viability through the formation of specific cAMP signalosomes that trigger either prodeath ...

The authors bioinformatically analyze previous scRNA-seq datasets of the developing mouse soft palate to identify differential signaling pathway activities in the heterogeneous palatal mesenchyme.

Canine IgG adsorption to NK-92 cells was performed as previously described (17 ... In addition, CD32B is expressed by human and mouse B cells and functions as an inhibitory receptor that blocks ...

We observed that IgM-BCR activation is dependent on mechanical forces and exhibits a multi-threshold effect. In contrast, the activation of isotype-switched IgG- or IgE-BCR only requires a low ...