The US Food and Drug Administration (FDA) has approved nipocalimab (Imaavy) injection for the treatment of adults and children aged 12 and older with generalized myasthenia gravis (gMG) who ...

The figure was created with www.biorender.com. T cells and B cells are the primary target cells of IL-21, and the expression of IL-21R on their cell membranes is upregulated following TCR and BCR ...

Our analysis of the Smad3-/- mouse now reveals the critical importance of this intermediate in mediating growth arrest in T cells following their activation through the antigen receptor, and its ...

While Bruton's Tyrosine Kinase (BTK) inhibitors have been approved for the treatment of B-NHL, resistance can arise through two major mechanisms: the BTK C481X mutation and BTK-independent BCR ...

Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged to treat IgG-mediated autoimmune disease. 4,5 Here, we review ...

The evidence supporting this mechanism is incomplete, with additional work needed to clarify SHP-1's role, the contribution of Fc receptor crosslinking, and the biological relevance ... However, the ...

(A) Percentage decrease (mean +/- SD) in viability upon DuoHexaBody-CD37 treatment in presence or absence of goat F(ab’)2 anti-human IgG (a-Fc) in indicated cell lines after 48h. Data is shown from at ...

and goat anti-rabbit IgG-Cy3, were obtained from Abmart (China). Mouse anti-IRF3 (CY5779), mouse anti-TBK1 (CY5145), and mouse anti-Lamin B1 (AB0054) antibodies were purchased from Abways (USA).

自身免疫性疾病中，致病的自身反应性 B 细胞产生机制不明。研究人员聚焦年龄相关性 B 细胞（ABCs），发现慢性 B 细胞受体（BCR）信号对其从无反应性 B 细胞分化至关重要，抑制 Btk 可减少 ABCs 数量，这为自身免疫性疾病治疗提供新思路。 在生命的长河中 ...