在此背景下，云南大学附属医院等研究机构的研究人员开展了关于 Integrin β3（ITGB3）的研究。ITGB3 作为整合素家族中研究较为广泛的成员，在肿瘤的进展和肿瘤微环境的重塑中发挥着多种关键作用，但此前其在泛癌中的表达和预后价值以及在调节肿瘤免疫方面的 ...

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In vitro, activation of cell division cycle 42 (Cdc42) maintained the morphological characteristics of quiescent HSCs. Cdc42 activation in HSC cell lines inhibited the expression of markers ...

为解决 Ephexin5（E5）在神经元可塑性调节中作用机制不明的问题，研究人员开展了 E5 对 Cdc42 和 RhoA 调控作用及相关机制的研究。结果表明 E5 可激活 Cdc42 和 RhoA，且其底物选择性受神经元活动和酪氨酸磷酸化调控，该研究为相关疾病治疗提供新思路。 大脑中的 ...

Read the paper: Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 Cells release sEVs to the extracellular environment.

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Department of Hygiene Toxicology, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China Key Laboratory of Maternal and Child Health and Exposure Science, Guizhou Provincial ...

The cadherin family, which includes T-cadherin, plays a significant role in angiogenesis, a critical process involved in tumor growth, metastasis, and recurrence. T-cadherin is extensively expressed ...

Furthermore, the expression of the angiogenic protein CD31 was increased in a dose-dependent manner. SCAP-derived EVs facilitated the transfer of Cdc42, a key factor in restructuring the cell ...