Rho家族GTP酶在PEDV诱导的信号通路中的作用 研究揭示了Rho家族GTP酶在PEDV诱导的Cofilin活性调节中的重要作用。Western blot分析显示，在感染初期，Cdc42和Rac1的活性被短暂诱导，而RhoA的活性未发生显著变化。进一步实验表明，Rac1和Cdc42的抑制剂能够阻断PEDV诱导的Cofilin ...

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R. China Bioinspired Engineering ...

LIMK activation leads to cofilin phosphorylation at Ser-3 resulting in the accumulation of F-actin. (VEGF: Vascular endothelial growth factor; ROCK: Rho-associated protein kinase; MRCK: myotonic ...

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate ...

Integrin activation recruits a host of focal adhesion components ... therefore amplifying their down-stream signaling cascades. These include ILK – CDC42 and ILK – Rac pathways, which regulate ...

2007; Bär et al., 2010). The angiogenic behaviour of CCN1 has been attributed to its binding to integrin αvβ3, a major integrin expressed in ECs (Leu et al., 2002). Ccn1-null mice suffer embryonic ...