We show that SFSWAP is a global regulator of retained intron splicing and exon skipping that primarily acts as a negative regulator of splicing. In contrast, knockdown of SFSWAP leads to reduced ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

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They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control and busy with rejecting a defective pre-mRNA. “When problems arise before ...

PEG-INTRON(R) Studied in a Wide Range of Hepatitis C Patient Populations Researchers Present 44 Abstracts on PEG-INTRON at Annual Meeting Of The American Association for The Study Of Liver ...

This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled at the sites where an exon joins an intron and the intron in turn connects to ...

Present limitations of the software comprise its inability to analyze insertion-deletions greater than 12 base pairs and alterations spanning an intron-exon border. Also, analysis of non-exonic ...

Spacedust is a modular toolkit for identification of conserved gene clusters among multiple genomes based on homology and conservation of gene neighborhood. Spacedust adapts the fast and sensitive ...