I’ll try to make this discussion as non-neurotoxic as possible. Glutamic acid receptors—including a subtype called kainate receptors belong to a class called ionotropic receptors. This is one of ...

Using an elegant and thorough experimental design, Thomazeau et al show that, in the developing mouse visual cortex, presynaptic NMDA receptors at layer 5 neocortical synapses mediate spike-timing ...

The nicotinic acetylcholine receptors (nAChRs) are the most well understood membrane receptors for neurotransmitters at the structural and functional level. They are integral allosteric membrane ...

The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled ...

This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). These ...

This manuscript presents a detailed characterization of male and female wildtype and Ctrp10 knockout mice, and reveals that knockout mice develop female-specific obesity that is largely uncoupled from ...

Two of the most studied forms of plasticity, long-term potentiation (LTP) and long-term depression (LTD), involve both glutamate and GABA (γ-aminobutyric acid) receptors, and it is becoming clear ...

These results are consistent with the action of TRPC4-specific inhibitor Pico145, suggesting that TRPC4 works as a functional ionotropic receptor of CBD. This study identified TRPC4 as a novel target ...

Mosquitoes possess three kinds of receptors that aid in sniffing out humans: odorant receptors (ORs), which detect alcohols and aldehydes; ionotropic receptors (IRs), which respond to acids and amines ...

Expression of the receptor subunits glutamate receptor, ionotropic, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA)-type subunit 1 (GRIA1) and 2 (GRIA2) was restricted to cells of mesenchymal ...