在这场与肥胖的 “战斗” 中，一种名为纤维连接蛋白 III 型结构域包含蛋白 5（FNDC5）的物质引起了科研人员的注意。它主要在骨骼肌中表达，其编码的跨膜蛋白经过一系列奇妙的变化，会产生一种叫做鸢尾素（Irisin）的物质。Irisin 就像是身体里的 “能量小卫士 ...

ABSTRACT: Background: Aging-induced cardiac hypertrophy and reduced skeletal muscle strength contribute to increased disease risk and life burden in the elderly. FNDC5 acts as a protective muscle ...

In animal experiments, KE group raised β-HB levels, decreasing body weight and blood lipids. KD with EX promoted WAT browning possibly via AMPK-SIRT1-PGC-1α, augmenting PRDM16, UCP1, FGF21, and FNDC5 ...

In the present study, we aimed to explore the relationship between the level of serum vitamin D and irisin concentrations in the older adults with sarcopenia. Conclusions: This study demonstrated that ...

Exercise helps beef up bones, but exactly how hasn’t been clear. A study published today (December 13) in Cell points to irisin, dubbed the “exercise hormone,” as a messenger between muscle and bone ...

Spiegelman’s group first identified irisin as a hormone released from human muscle during physical activity in 2012. It has been a source of scientific contention ever since. Three years ago, ...