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Irisin:调控小胶质细胞极化与自噬,对抗术后认知功能障碍的新希望
术后认知功能障碍(POCD)是影响中枢神经系统的严重并发症,其主要病理机制为小胶质细胞诱导的神经炎症。研究人员开展了关于 Irisin 对 POCD 保护作用及机制的研究,发现 Irisin 可缓解小鼠认知缺陷,调控小胶质细胞极化,其作用依赖 Sirt 3 通路,为 POCD 治疗 ...
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