为探究此问题，研究人员以结肠癌为研究对象，聚焦 mutant p53（mutp53）。研究发现 mutp53 通过上调 HDAC6，维持 Ku70 水平，减轻 ER 应激诱导的 DNA 损伤。该成果为攻克 mutp53 相关癌症提供新方向。 在癌症的复杂世界里，癌细胞就像一群顽强的 “敌人”，拥有多种 ...

The involvement of the Ku70 protein also hints at a role of the Mlp proteins in regulating DNA repair. The obvious next step is to determine whether an association between NPC core proteins ...

PEX5 was revealed as a target gene of miR-4274, with the deletion genotype of rs1553867776 leading to downregulation of PEX5 protein ... that PEX5 interacts with Ku70 in the cytoplasm, preventing ...