本研究针对LRRK2突变型帕金森病（PD）患者缺乏路易小体（LBs）但临床表现符合路易小体病（LBD）的矛盾现象，通过邻近连接实验（PLA）首次揭示此类病例存在广泛非包涵体α-突触核蛋白（α-synuclein）聚集。研究发现LRRK2病例中颗粒状PLA信号在脑桥小脑束和下橄榄 ...

为解决氟哌啶醇（Haloperidol）治疗神经精神疾病时引发类似帕金森病运动障碍副作用机制不明的问题，研究人员开展了 LRRK2 对 Haloperidol 影响的研究。结果发现 LRRK2 激酶参与相关信号通路，其抑制可减轻副作用。这为神经疾病治疗提供新思路。 在神经科学的领域 ...

In 1963, Christian de Duve first postulated the concept of “autophagy” (de Duve, 1963). The term has since then been universally adopted to describe the evolutionary conserved mechanism that allows ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D (CTSD ...

Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, ...

Mutations in the gene LRRK2 are also responsible for Parkinson's disease, and previous research has shown that these proteins accumulate around damaged lysosomes as well. In the new study ...

Figure 1: Representative images of the induction of autophagy and the outcome of its suppression. Figure 2: The role of autophagy in development and differentiation in mammals.