(Phospho)proteomic analyses of cellular models of LRRK2 and PINK1 should aid the ... cell to remove aggregating protein may involve both autophagy and the UPS. Released aggregated α-synuclein ...

The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well. Their ability to identify new genes involved in autophagy and ...

Their findings point to mutations in the LRRK2 gene as a common element linking ... inflammation, and autophagy, the body's cellular recycling system, that are involved in both conditions.