Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

Northwestern Medicine scientists have uncovered new insights into how neurofilaments act like Velcro in neurodegenerative diseases, clogging up the brain and preventing normal function, according to a ...

Carpal boss is usually associated with a traumatic injury to the hand and fingers or repetitive hand use. A carpal boss is often mistakenly misdiagnosed as a ganglion cyst because of the similarity in ...

The center–surround receptive-field organization in retinal ganglion cells is widely believed to result mainly from lateral inhibition at the first synaptic level (in the outer retina).

Some altered sensation in the legs can also occur. VZV causes shingles after being reactivated in the dorsal root ganglion near the spinal cord, resulting in a very painful rash. Myelitis may come on ...

Amyotrophic lateral sclerosis (ALS) has traditionally been associated with brain damage involving ... On this latter regard, there is still a shortage of studies which investigated basal ganglia (BG) ...

Figure 1. STN, subthalamic nucleus; GPe, globus pallidus externus; GPi, globus pallidus internus; LHb, lateral habenula. The canonincal basical ganglia model, with an associated direct, indirect, and ...