"The JAK2 mutation is not present in everyone with myelofibrosis, and there are other mutations as well." A second key ...

Identifying the JAK2V617F mutation has improved understanding of what causes overproduction of red blood cells, platelets, ...

Importantly, the new study discovered that all major JAK2 mutation types—exon 12 (causing polycythemia vera), V617F (80% of all three types of MPN), and exon 16 (acute lymphoid leukemia ...

To investigate the therapeutic potential of targeting JAK/STAT in t(8;21) leukemia, we examined the effects of a JAK2-selective inhibitor TG101209 and a JAK1/2-selective inhibitor INCB18424 on t(8 ...

such as JAK2 exon 12 mutations • Sustained platelet count ≥ 450 × 10 9 /l • Bone marrow biopsy specimen showing proliferation mainly of the megakaryocytic lineage with increased numbers of ...

Among patients with calreticulin (CALR)-mutated myelofibrosis, real-world data reveal insights into those with splenomegaly and/or symptoms requiring therapy with Janus kinase 2 (JAK2) inhibitors. The ...