Researchers in pharma and beyond have historically glommed onto a limited number of disease targets, limiting innovation. AI ...

G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...

Among methods employed in drug discovery, pharmacophore modelling, multi-dimensional quantitative structure activity relationships (such as, 4- and 3D-QSAR), Comparative Molecular Field Analysis ...

We note that examination of the structures showed similarity in the binding mode for all structures that bind to the same drug and little if any difference between monomeric chains with respect to ...

Drug promiscuity can also be evaluated from the ... provided the original work is properly cited. Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological ...

Precious metals are not merely ornaments; they are also important components of pharmaceuticals, like the antitumor drug ...

In April 2025, Actelion announced a study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the ...

Abstract: Predicting protein-ligand binding affinities is a critical problem in drug discovery and design. A majority of existing methods fail to accurately characterize and exploit the geometrically ...

Pulmonary arterial hypertension (PAH) is a rare form of pulmonary hypertension. It occurs because progressive vascular ...

Sapio Sciences has integrated the NVIDIA BioNeMo platform into its lab informatics platform, enhancing AI-driven ...

P2Rank: Protein-ligand binding site prediction from protein structure based on machine learning.

Ligand Pharmaceuticals Incorporated, a biopharmaceutical company, develops and licenses biopharmaceutical assets worldwide. It offers Pradefovir, Posaconazole, Voriconazole, CAPVAXIVE, NOXAFIL ...