Using the light sheet method means less damage to your sample from laser exposure, which is great for imaging delicate things like embryos, larvae, and organoids. You can use it to image alive, ...

A light sheet fluorescence microscopy approach for the analysis of immune cell composition, vascularization, tissue perfusion and hypoxia enables spatial imaging of the tissue microenvironment in ...

LightSheet microscopy is a fluorescence technique that projects a thin ‘sheet’ of excitation light perpendicular to the direction of observation ... Emission signal from this volume is collected by a ...

High quantum efficiency detectors enable observations of the fastest processes at the lowest illumination light levels. The light sheet geometry illuminates only the parts of the sample you are ...

While medical centers use ultrasound daily, so far this technology is not capable of observing body tissues at the scale of cells.

The Zeiss LightSheet Z.1 is a stand-alone SPIM (Side Plane Illumination Microscope) capable of imaging large, living specimens at much greater speeds than more traditional confocal technology. It is ...

However, Dr. Daetwyler said, light-sheet microscopy comes with a significant drawback: The higher the imaging resolution, the smaller the area researchers can image. Thus, scientists have had to ...

The end result is data equivalent to conventional light-sheet microscopy, but requiring a single, stationary objective lens, no sample translation, and consequently very high speed 3-D imaging.