In human cells, lipid droplets (LDs) predominantly contain either cholesteryl esters or triacylglycerols. This article ...

近年来，随着蛋白质组学技术的飞速发展，科研人员逐渐揭开了蛋白质翻译后修饰（PTM）在疾病发生发展中的重要作用。其中棕榈酰化（S-palmitoylation）作为一种重要的脂质修饰方式，逐渐成为研究热点。棕榈酰化通过在蛋白质的半胱氨酸残基上添加棕榈酸（PA），调控蛋白质的稳定性、定位和功能，进而影响多种生理和病理过程。

细胞器是真核细胞的标志性特征，但关于细胞器的生物发生仍有许多未知。脂质滴（lipid droplets）和过氧化物酶体（peroxisomes）在脂肪的储存和分解代谢中发挥相反作用，它们从内质网（endoplasmic reticulum，ER）的一个神秘区域形成。研究人员利用活细胞荧光显微镜 ...

Lipid accumulation in tumor cells and nearby immune cells promotes immune suppression and therapy resistance in ...

Once thought to be little more than blobs of fat inside eukaryotic cells, lipid droplets may in fact provide a first line of defence against invading pathogens, according to evidence published today ...

in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly the lab studies the mechanisms how cells regulate the abundance of lipids, how they ...

However, some initially responsive tumors still develop recurrences. Researchers studied mouse models and found that TNBC ...