Many of these molecules, according to Christian Jones, chief commercial officer at Nanoform, represent increasing structural diversity, complexity, and lipophilicity, with many insoluble in aqueous ...

In general, for oral drugs approved since 1983, there has been an increase in molecular mass, O plus N atom count and OH plus NH count, whereas lipophilicity has remained relatively unchanged.

Department of Analytical Chemistry, Belarusian State University, Leningradskaya Str., 14, Minsk 220030, Belarus Research Institute for Physical Chemical Problems of the Belarusian State University, ...

POMs are a class of inorganic metal-oxygen cluster compounds with broad-spectrum antitumor potential. However, their strong hydrophilicity and poor lipophilicity result in insufficient cell membrane ...

Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan Graduate School of Science and Technology, Nara Institute of ...

Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high ...

Heterocyclic scaffolds not only offer opportunities to enhance the drug's permeability through the plasma membrane by increasing its lipophilicity but also have the potential to improve aqueous ...