Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Researchers have long wondered why some people with high-risk Parkinson’s gene variants develop the disease while others ...

Any proteins that are destined for a lysosome are delivered to the lysosome interior when the vesicle that carries them fuses with the lysosomal membrane and joins its contents. In contrast ...

By using tiny, naturally occurring particles called extracellular vesicles (EVs), they have created a way to boost the body's immune system to fight tumors more effectively. This breakthrough ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...

Cargo proteins that are destined for lysosomal degradation are first incorporated into intraluminal vesicles (ILVs), which form by the invagination of endosomes; this process turns endosomes into ...

But why lysosomal dysfunction causes neuroinflammation ... This "transmembrane" region is known to house a channel that helps membranous vesicles, such as lysosomes, regulate pH—a measure ...

Based on their findings, they propose a targeted lysosomal dysfunction strategy for the treatment of glioblastoma. Lysosomes perform important biochemical functions. Apart from degrading 'waste ...

The Lysosomal Metabolomics and pH Core’s overarching goal is to understand the mechanistic link between lysosomal activity and aging in Alzheimer’s Disease. To accomplish this, the core will support ...