Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Cargo proteins that are destined for lysosomal degradation are first incorporated into intraluminal vesicles (ILVs), which form by the invagination of endosomes; this process turns endosomes into ...

These vesicles were shown to contain fragments of mitochondria and endoplasmic reticulum as well as lysosomal enzymes. In a conference on lysosomes in 1963, Christian de Duve appropriately coined ...

Researchers have long wondered why some people with high-risk Parkinson’s gene variants develop the disease while others ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a quality control sensor for organelles that serve as cellular waste disposal ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...

Based on their findings, they propose a targeted lysosomal dysfunction strategy for the treatment of glioblastoma. Lysosomes perform important biochemical functions. Apart from degrading 'waste ...