The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...

Lysosomal dysfunction is a common feature of several neurodegenerative diseases, including PD. The lysosome is the recycling center of the cell, responsible for breaking down waste material, old cell ...

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

Recent studies have identified the reprogramming of lipid metabolism as a critical hallmark of malignancy. Enhanced cholesterol uptake and increased cholesterol biosynthesis significantly contribute ...

To date, knowledge about the pathogenic mechanisms underlying orthoflavivirus infection and the interactions of these viruses with host cells is limited. Mammalian target of rapamycin (mTOR) is ...

The authors note that, due to a printer's error, the author name Eric H. Baehreck should have appeared as Eric H. Baehrecke. Additionally, the author name Christina McPhee should have appeared as ...

Note: The article usage is presented with a three- to four-day delay and will update daily once available. Due to ths delay, usage data will not appear immediately following publication. Citation ...

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells' major recycling centers, and on an enzyme called cathepsin B. In Alzheimer's disease ...

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells' major recycling centers, and on an enzyme called cathepsin B. In Alzheimer's disease ...

According to the authors in Science Advances, this mechanism relies on a protein complex known as retromer and the lysosomes—cell organelles containing digestive enzymes. These special cellular ...

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, ...