Research on guinea pig embryos uncovers similarities to human embryogenesis, advancing understanding of preimplantation ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

肝细胞癌（HCC）治疗面临困境，现有疗法效果有限。研究人员开展了关于 L-741626 对 HCC 作用的研究。结果发现 L-741626 能抑制 HCC 进展，还可与索拉非尼协同增效。该研究为 HCC 治疗提供了新方向。

为解决结直肠癌（CRC）转移机制不明及缺乏有效治疗靶点的问题，研究人员开展了关于长链非编码 RNA LINC02167 在 CRC 转移中作用的研究。结果发现 LINC02167 通过 m 5 C 修饰稳定 KSR1 mRNA，激活 ERK/MAPK 通路促进转移。这为转移性 CRC 治疗提供了新靶点。

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention ...

These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that’s involved in stress-induced defense ...

Describing their results in Nature Microbiology (“ERK pathway reactivation prevents ... disrupting important MAPK pathways, and rapidly causing widespread cellular, tissue, and organ damage ...

The results demonstrate that compared to avutometinib alone, the FAK inhibitor/avutometinib combination inhibits RAS/MAPK pathway signaling more deeply while also blocking key adaptive resistance ...

B-raf proto-oncogene (BRAF) encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein is part of the MAPK/ERK signaling pathway, which affects cell division, ...

Its pipeline includes Tipifarnib, which is a Farnesyl transferase inhibitor for HRAS Mutant Solid Tumors, Chronic Myelomonocytic Leukemia, KO-947, which is an ERK inhibitor for MAPK Pathway Tumors ...