Overexpression of WT HER4 resulted in increased levels of phosphorylated p38 MAPK (T180/Y182) (p=0.04), Src (Y416) (p<0.001) and STAT3 (Y705) (p<0.001). The 8 HER4 MUTs assessed had no impact on the ...

血小板减少症治疗手段有限。西南医科大学研究人员开展了以米替福新靶向 CCR5 治疗血小板减少症的研究。结果显示米替福新可促进巨核细胞（MK）分化和血小板生成，这为血小板减少症治疗提供了新策略。

在结直肠癌（CRC）治疗中，BRAFV600E突变患者预后差，BRAF 和 EGFR 抑制剂联合疗法虽有应用，但存在耐药问题。研究人员开展了关于 LSD1 抑制对 BRAF 突变型 CRC 靶向治疗影响的研究，发现抑制 LSD1 可阻断细胞谱系可塑性，有望改善患者治疗反应。

The University of Texas MD Anderson Cancer Center, Houston, TX.

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

(A) Percentage decrease (mean +/- SD) in viability upon DuoHexaBody-CD37 treatment in presence or absence of goat F(ab’)2 anti-human IgG (a-Fc) in indicated cell lines after 48h. Data is shown from at ...