研究解读 Hypocrellin A （HA）又名竹红菌素A，具有抗肿瘤活性。本研究预验证HA可通过抑制PI3K-AKT-mTOR、MAPK 和STAT3 信号通路对抗肝内胆管癌。PI3K-AKT-mTOR信号通路在响应各种细胞刺激和调节基本细胞活动中起着至关重要的作用，包括转录、翻译、增殖、存活和生长等。

Overexpression of WT HER4 resulted in increased levels of phosphorylated p38 MAPK (T180/Y182) (p=0.04), Src (Y416) (p<0.001) and STAT3 (Y705) (p<0.001). The 8 HER4 MUTs assessed had no impact on the ...

血小板减少症治疗手段有限。西南医科大学研究人员开展了以米替福新靶向 CCR5 治疗血小板减少症的研究。结果显示米替福新可促进巨核细胞（MK）分化和血小板生成，这为血小板减少症治疗提供了新策略。

在结直肠癌（CRC）治疗中，BRAFV600E突变患者预后差，BRAF 和 EGFR 抑制剂联合疗法虽有应用，但存在耐药问题。研究人员开展了关于 LSD1 抑制对 BRAF 突变型 CRC 靶向治疗影响的研究，发现抑制 LSD1 可阻断细胞谱系可塑性，有望改善患者治疗反应。

The University of Texas MD Anderson Cancer Center, Houston, TX.

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with high mortality, and effective treatment strategies remain limited. This study investigated the effects of benzethonium ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

In February 2024, the company initiated subject dosing in a Phase I trial of VVD-130850, an investigational oral STAT3 inhibitor aimed at treating advanced solid and haematologic tumours.

In addition to VVD-159642, the company is conducting other Phase I trials assessing an oral, Kelch-like, ECH-associated protein 1 (KEAP1) activator, as well as an oral signal transducer and activator ...