白芍，作为毛茛科植物芍药（Paeonia lactiflora Pall.）的干燥根，在中国的传统医学中扮演着重要角色，历久弥新。早在《神农本草经》中，白芍就被认定为具有‘味苦，平’的药材，主要作用于调理气血、缓解腹痛等。随着时间的推移，白芍逐渐被分为赤芍和白芍 ...

在铁死亡对 JAK/STAT 信号通路的调节研究中，发现铁死亡可通过激活 p38 MAPK 通路，进而磷酸化和激活 STAT6，促进促血管生成和炎症细胞因子的表达，在子宫内膜异位症的发展中发挥作用。同时，铁死亡诱导剂 SSPH I 可激活 STAT3，这表明 STAT3 可能参与癌细胞对铁 ...

DCs interact with different immune cells to dictate the immune response. This interaction may be direct (T-cells), or indirect (with B-cells, eosinophils, neutrophils, mast cells and basophils ...

Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a ...

The mitochondrial metabolisms appears to be involved in this regulation. This study is well performed, and the manuscript is clearly written. Here, we establish dynamic roles for the ERK MAPK pathway ...

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity ...

2014). Signal transducer and activator of transcription 3 (STAT3) plays an important role in neural progenitor self-renewal and differentiation. As a member of the STAT family, STAT3 responds to ...

These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2, STAT3 and MAPK signaling proteins. In addition, there is inhibition of expression of ...